KMID : 1145520190050020152
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Journal of Radiopharmaceuticals and Molecular Probes 2019 Volume.5 No. 2 p.152 ~ p.157
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Development of radiotracer for polo-box domain of polo-like kinase 1
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Ryu Eun-Kyoung
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Abstract
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Polo-like kinase 1 (Plk1) is crucial regulator of cell cycle progression during mitosis. It is known to highlyoverexpress in many different tumor types, and has been implicated as a potential antimitotic cancer target.
The phosphopeptide, Pro-Leu-His-Ser-p-Thr (PLHSpT), was shown a high level of affinity and specificity forthe polo-box domain (PBD) of Plk1. However, the peptide has the limitation of cell permeability. We designedthe derivatives to enhance the limitation of PLHSpT using drug delivery system. In addition, we synthesizedand evaluated its radiotracer for tumor diagnosis. This review discusses the derivative and radiotracer that aresuitable for tumor treatment and diagnosis for PBD of Plk1.
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KEYWORD
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Polo-like kinase 1, Polo-box domain, PLHSpT, Radiotracer, Tumor, Treatment, Diagnosis
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